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A gift to the UCSF Department of Surgery can help physicians and scientist find treatments and cures for serious liver diseases such as hepatitis B & C, and liver cancer.
Carlos U. Corvera, M.D.
Associate Professor of Surgery
Chief, Hepatobiliary and Pancreas Surgery
Division of General Surgery
Contact Information
Helen Diller Family Comprehensive Cancer Center
1600 Divisadero Street, 4th Floor
San Francisco, CA 94115
tel: 415/353-9888
fax: 415/353-9931
carlos.corvera@ucsfmedctr.org
BiographyEducation
- 1983-86 University of California, Davis, CA B.S. Biochemistry College of Agricultural and Environmental Science
- 1989-93 University of California, San Diego Medical School. M.D. La Jolla, CA
Residencies
- 1993-1995,University of California, San Francisco, Intern and Resident,Surgery
- 1995-1998 University of California, San Francisco, Research Fellow Surgery, Division of Gastrointestinal Surgery
- 998-2000,University of California, San Francisco, Senior Resident Surgery
- 2000-2001,University of California, San Francisco, Chief Resident Surgery
Fellowships
- 2001-2002, Memorial Sloan-Kettering Cancer Center, Fellow ,Surgical Oncology, New York, New York
- 2002-2003, Memorial Sloan-Kettering Cancer Center, Fellow, Hepatobiliary Surgery, New York, New York
Board Certification
- American Board of Surgery
Program Affiliations
- Hepatobiliary and Pancreas Surgery Program
- UCSF Department of Surgery at the San Francisco VA
- UCSF Helen Diller Family Comprehensive Cancer Center
Clinical Expertise
- Ascites
- Bile Duct Cancer (Cholangiocarcinoma)
- Bile Duct Injuries
- Bile Duct Strictures
- Bridging Therapies to Downstage HCC in Setting of Liver Transplantation
- Choledochal Cysts
- Gallbladder Cancer
- Gastrointestinal Carcinoid Tumor
- Gastrointestinal Stromal Tumor (GIST)
- Liver Cancer (Hepatocellular Carcinoma)
- Liver Cysts
- Liver Metastases
- Melanoma
- Minimally Invasive Liver & Pancreas Surgery
- Pancreatic Cancer
- Pancreatic Cysts
- Pancreatic Neuroendocrine (Islet Cell) Tumors
- Portal Hypertension
- Soft Tissue Sarcomas
- Stomach (Gastric) Cancer
Research Interests
Proteases and Proteinase Activated Receptors in the Biliary Tract
Biography
Carlos Corvera, M.D. is Associate Professor of Surgery and Chief of Hepatobiliary and Pancreas Surgery at UCSF. A trained surgical oncologist, Dr. Corvera has extensive experience in the treatment of benign and malignant hepatobiliary disease including hepatocellular carcinoma (primary liver cancer), liver metastases, and cancers of the stomach, gall bladder, bile ducts, and pancreas. Additionally, Dr. Corvera performs surgery for melanoma and soft tissue sarcomas. Dr. Corvera specializes in complex and intricate cancer surgeries, including minimally invasive liver resections that greatly minimize post-operative pain and speed recovery. Dr. Corvera, who performs a high volume of such procedures, is also a pioneer and innovator of surgical techniques in the field.
Dr. Corvera graduated from the University of California San Diego School of Medicine. He completed his general surgery residency at UCSF, and prestigious fellowships in surgical oncology and hepatobiliary surgery at Memorial Sloan-Kettering Cancer Center.
Research Summary
Dr. Covera's scientific research interest is focused on understanding the mechanisms of biliary tract fibrosis and inflammation. More specifically, he is interested in studying the clinical consequences of biliary fibrosis-- mainly cholestatisis. Cholestasis is characterized by impaired bile flow causing a high concentration of bile acids in the liver and the circulation. Prolonged exposure to bile acids in the liver can progress to end-stage liver disease and cirrhosis. In the gastrointestinal tract, the absence of bile flow causes profound local and systemic metabolic disturbances. Dr. Covera is actively investigating the role of a novel cell surface receptor specific for bile acids that may play a critical role in normal and disease states.
Selected Publications
- Corvera, C.U., Déry, O., McConalogue, K.M., Böhm, S.K., Khitin, L.M., Kong, W., Caughey, G.H., Payan, D.G., Bunnett, N.W. Mast cell tryptase regulates colonic myocytes through proteinase-activated receptor-2. Journal of Clinical Investigation 100: 1997, pp.1383-1393. Role: Study conception and design, conducted experiments, data analysis and manuscript preparation.
- Corvera, C.U., Déry, O, McConalogue K., Gamp, P., Thoma, M. Bahjat A. Caughey G.H., Hollenberg, M.D., Bunnett, N.W. Thrombin and mast cell tryptase regulate guinea pig myenteric neurons through proteinase-activated receptors-1 and -2. Journal of Physiology 517.3 :1999, pp.741-756. Role: Study conception and design, conducted experiments, data analysis and manuscript preparation.
- Chang TT, Sawhney R, Monto A, Davoren BJ, Kirkland JG., Stewart L, and Corvera C.U. A Multidisciplinary Treatment Team for Patients with Hepatocellular Cancer at a Veterans Affairs Medical Center Improves Survival. Hepato Pancreato Biliary International Association (HPB), 2008;10(6), pp. 405-411. Role: Study conception and manuscript preparation.
- Chang, T.T, and Corvera, C.U. The "Caudate Split" Maneuver for Laparoscopic and Open Liver Resections. Am Coll Surg. 2008 Dec; 207(6) pp. e7 e-9. Role: Study conception and manuscript preparation.
- Kirkland, J.G., Cottrell, G.S. Bunnett, N.W. and Corvera,C.U. Agonist of PAR1 and PAR2 stimulate electrogenic secretion in Mouse gallbladder. Am J Physiol Gastrointest Liver Physiol. 293(1): 2007. pp. G335-46, 2007. Role: Study conception and design, conducted experiments, data analysis and manuscript preparation.
In the News
New Hepatobiliary Service to be Led by Carlos Corvera, M.D.
UCSF Department of Surgery - Jul 01, 2011The Department of Surgery announces the launching of a new multidisciplinary service, the Hepatobiliary Service as of July 1, 2011 under the direction of Dr. Carlos Corvera. This new multidisciplinary program will bring faculty members together from Surgery, Hepatology, Medical Oncology, Anesthesia, Radiology and Pathology to care for patients with benign and malignant conditions of the liver, gallbladder and biliary tract. The service will hold clinics at the Mt. Zion campus on Wednesdays (all day) and on Thursday afternoons. A weekly Tumor Board at Mt. Zion will augment the weekly Parnassus Tumor Board. The Department believes the creation of this program will enhance care of these patients.
